A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression

The cohesin complex spatially organizes interphase chromatin by bringing distal genomic loci into close physical proximity, looping out the intervening DNA. Mutation of cohesin complex subunits is observed in cancer and developmental disorders, but the mechanisms through which these mutations may co...

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Detalles Bibliográficos
Autores principales: Carico, Zachary M., Stefan, Holden C., Justice, Megan, Yimit, Askar, Dowen, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990204/
https://www.ncbi.nlm.nih.gov/pubmed/33760811
http://dx.doi.org/10.1371/journal.pgen.1009435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990204/
https://www.ncbi.nlm.nih.gov/pubmed/33760811
http://dx.doi.org/10.1371/journal.pgen.1009435

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