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A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression
The cohesin complex spatially organizes interphase chromatin by bringing distal genomic loci into close physical proximity, looping out the intervening DNA. Mutation of cohesin complex subunits is observed in cancer and developmental disorders, but the mechanisms through which these mutations may co...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990204/ https://www.ncbi.nlm.nih.gov/pubmed/33760811 http://dx.doi.org/10.1371/journal.pgen.1009435 |