A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

A synthetic lethal effect arises when a cancer-associated change introduces a unique vulnerability to cancer cells that makes them unusually susceptible to a drug’s inhibitory activity. The synthetic lethal approach is attractive because it enables targeting of cancers harboring specific genomic or...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Zhang, Shenqiu, Shi, Qiong, Allen, Thaddeus D., You, Fengming, Yang, Dun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990233/
https://www.ncbi.nlm.nih.gov/pubmed/33760847
http://dx.doi.org/10.1371/journal.pone.0248355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990233/
https://www.ncbi.nlm.nih.gov/pubmed/33760847
http://dx.doi.org/10.1371/journal.pone.0248355

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