What is the Pathogenic CAG Expansion Length in Huntington’s Disease?

Huntington’s disease (HD) (OMIM 143100) is caused by an expanded CAG repeat tract in the HTT gene. The inherited CAG length is known to expand further in somatic and germline cells in HD subjects. Age at onset of the disease is inversely correlated with the inherited CAG length, but is further modul...

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Detalles Bibliográficos
Autores principales: Donaldson, Jasmine, Powell, Sophie, Rickards, Nadia, Holmans, Peter, Jones, Lesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990448/
https://www.ncbi.nlm.nih.gov/pubmed/33579866
http://dx.doi.org/10.3233/JHD-200445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990448/
https://www.ncbi.nlm.nih.gov/pubmed/33579866
http://dx.doi.org/10.3233/JHD-200445

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