eIF2B conformation and assembly state regulate the integrated stress response

The integrated stress response (ISR) is activated by phosphorylation of the translation initiation factor eIF2 in response to various stress conditions. Phosphorylated eIF2 (eIF2-P) inhibits eIF2’s nucleotide exchange factor eIF2B, a twofold symmetric heterodecamer assembled from subcomplexes. Here,...

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Detalles Bibliográficos
Autores principales: Schoof, Michael, Boone, Morgane, Wang, Lan, Lawrence, Rosalie, Frost, Adam, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990499/
https://www.ncbi.nlm.nih.gov/pubmed/33688831
http://dx.doi.org/10.7554/eLife.65703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990499/
https://www.ncbi.nlm.nih.gov/pubmed/33688831
http://dx.doi.org/10.7554/eLife.65703

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