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eIF2B conformation and assembly state regulate the integrated stress response
The integrated stress response (ISR) is activated by phosphorylation of the translation initiation factor eIF2 in response to various stress conditions. Phosphorylated eIF2 (eIF2-P) inhibits eIF2’s nucleotide exchange factor eIF2B, a twofold symmetric heterodecamer assembled from subcomplexes. Here,...
Autores principales: | Schoof, Michael, Boone, Morgane, Wang, Lan, Lawrence, Rosalie, Frost, Adam, Walter, Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990499/ https://www.ncbi.nlm.nih.gov/pubmed/33688831 http://dx.doi.org/10.7554/eLife.65703 |
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