Structural basis for non-radical catalysis by TsrM, a radical-SAM methylase

TsrM methylates C2 of the indole ring of L-tryptophan (Trp) during the biosynthesis of the quinaldic acid moiety of thiostrepton. It is annotated as a cobalamin-dependent radical S-adenosylmethionine (SAM) methylase; however, TsrM does not reductively cleave SAM to the universal 5ʹ-deoxyadenosyl 5ʹ-...

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Detalles Bibliográficos
Autores principales: Knox, Hayley L., Chen, Percival Yang-Ting, Blaszczyk, Anthony J., Mukherjee, Arnab, Grove, Tyler L., Schwalm, Erica L., Wang, Bo, Drennan, Catherine L., Booker, Squire J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990684/
https://www.ncbi.nlm.nih.gov/pubmed/33462497
http://dx.doi.org/10.1038/s41589-020-00717-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990684/
https://www.ncbi.nlm.nih.gov/pubmed/33462497
http://dx.doi.org/10.1038/s41589-020-00717-y

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