Cargando…
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis
INTRODUCTION: Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) has become the most common disabling joint disease, without effective disease-modifying treatment causing a large social and economic burden. In this study we set out to explore responses of aged human...
Autores principales: | Houtman, Evelyn, van Hoolwerff, Marcella, Lakenberg, Nico, Suchiman, Eka H. D., van der Linden-van der Zwaag, Enrike, Nelissen, Rob G. H. H., Ramos, Yolande F. M., Meulenbelt, Ingrid |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991015/ https://www.ncbi.nlm.nih.gov/pubmed/33608843 http://dx.doi.org/10.1007/s40744-021-00287-y |
Ejemplares similares
-
RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets
por: Tuerlings, Margo, et al.
Publicado: (2021) -
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants
por: Houtman, Evelyn, et al.
Publicado: (2021) -
RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2019) -
Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants
por: van Hoolwerff, Marcella, et al.
Publicado: (2022) -
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
por: Tuerlings, Margo, et al.
Publicado: (2021)