Risk compensation after HIV-1 vaccination may accelerate viral adaptation and reduce cost-effectiveness: a modeling study

Pathogen populations can evolve in response to selective pressure from vaccine-induced immune responses. For HIV, models predict that viral adaptation, either via strain replacement or selection on de novo mutation, may rapidly reduce the effectiveness of an HIV vaccine. We hypothesized that behavio...

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Detalles Bibliográficos
Autores principales: Peebles, Kathryn, Mittler, John E., Goodreau, Steven M., Murphy, James T., Reid, Molly C., Abernethy, Neil, Gottlieb, Geoffrey S., Barnabas, Ruanne V., Herbeck, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991033/
https://www.ncbi.nlm.nih.gov/pubmed/33762616
http://dx.doi.org/10.1038/s41598-021-85487-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991033/
https://www.ncbi.nlm.nih.gov/pubmed/33762616
http://dx.doi.org/10.1038/s41598-021-85487-w

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