Transcriptional Inhibition of lncRNA gadd7 by CRISPR/dCas9-KRAB Protects Spermatocyte Viability

Our previous study found that lncRNA gadd7 was up-regulated in the semen of varicocele patients, and could promote the apoptosis of mouse spermatocytes and inhibit their proliferation. Therefore, we further explored whether down-regulation of Gadd seven expression could protect the viability of sper...

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Detalles Bibliográficos
Autores principales: Zhao, Jun, Ma, Wenmin, Zhong, Yucheng, Deng, Hao, Zhou, Bingyu, Wu, Yaqin, Yang, Meiqiong, Li, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991575/
https://www.ncbi.nlm.nih.gov/pubmed/33778010
http://dx.doi.org/10.3389/fmolb.2021.652392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991575/
https://www.ncbi.nlm.nih.gov/pubmed/33778010
http://dx.doi.org/10.3389/fmolb.2021.652392

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