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Prediction of Function Determining and Buried Residues Through Analysis of Saturation Mutagenesis Datasets
Mutational scanning can be used to probe effects of large numbers of point mutations on protein function. Positions affected by mutation are primarily at either buried or at exposed residues directly involved in function, hereafter designated as active-site residues. In the absence of prior structur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991590/ https://www.ncbi.nlm.nih.gov/pubmed/33778004 http://dx.doi.org/10.3389/fmolb.2021.635425 |