Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

The dual-specificity phosphatase 3 (DUSP3), an atypical protein tyrosine phosphatase (PTP), regulates cell cycle checkpoints and DNA repair pathways under conditions of genotoxic stress. DUSP3 interacts with the nucleophosmin protein (NPM) in the cell nucleus after UV-radiation, implying a potential...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Lilian C., Ferruzo, Pault Y. M., Forti, Fabio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991746/
https://www.ncbi.nlm.nih.gov/pubmed/33777934
http://dx.doi.org/10.3389/fcell.2021.624933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991746/
https://www.ncbi.nlm.nih.gov/pubmed/33777934
http://dx.doi.org/10.3389/fcell.2021.624933

Ejemplares similares