DDRE-12. HETEROGENOUS RESPONSE OF IDH-MUTANT AND IDH-WT GLIOMA TO NAMPT INHIBITION

BACKGROUND: NAD+ is required for cell metabolism and DNA repair. It is generated from nicotinic acid (NA) by NAPRT and from Nicotinamide (NAM) by NAMPT. D2HG in IDH-mutant tumors methylates and inactivates NAPRT, increasing dependence on NAMPT. Toxic side effects of NAMPT inhibition can be prevented...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahman, Masum, Hirte, Renee, Olson, Ian, Mansour, Moustafa, Ikram, Samar, MunozCasabella, Amanda, Sutiwisesak, Rujapope, Carlstrom, Lucas, Warrington, Arthur, Rajani, Karishma, Sarkaria, Jann, Burns, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992232/
http://dx.doi.org/10.1093/noajnl/vdab024.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992232/
http://dx.doi.org/10.1093/noajnl/vdab024.034

Ejemplares similares