Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

BACKGROUND: Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models. In a previous study, we generated an EOfAD-like mutation, psen1(Q96_K97del...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Yang, Newman, Morgan, Pederson, Stephen M., Barthelson, Karissa, Hin, Nhi, Lardelli, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992352/
https://www.ncbi.nlm.nih.gov/pubmed/33761877
http://dx.doi.org/10.1186/s12864-021-07509-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992352/
https://www.ncbi.nlm.nih.gov/pubmed/33761877
http://dx.doi.org/10.1186/s12864-021-07509-1

Ejemplares similares