Cargando…
Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment
BACKGROUND: SARS-CoV-2 causes COVID-19 with a widely diverse disease profile that affects many different tissues. The mechanisms underlying its pathogenicity in host organisms remain unclear. Animal models for studying the pathogenicity of SARS-CoV-2 proteins are lacking. METHODS: Using bioinformati...
Autores principales: | Zhu, Jun-yi, Lee, Jin-Gu, van de Leemput, Joyce, Lee, Hangnoh, Han, Zhe |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992514/ https://www.ncbi.nlm.nih.gov/pubmed/33766136 http://dx.doi.org/10.1186/s13578-021-00567-8 |
Ejemplares similares
-
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor
por: Lee, Jin-Gu, et al.
Publicado: (2021) -
SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
por: Zhu, Jun-yi, et al.
Publicado: (2022) -
Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2
por: van de Leemput, Joyce, et al.
Publicado: (2021) -
H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development
por: Zhu, Jun-yi, et al.
Publicado: (2023) -
Understanding Individual SARS-CoV-2 Proteins for Targeted Drug Development against COVID-19
por: van de Leemput, Joyce, et al.
Publicado: (2021)