Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy

BACKGROUND: Non-ischemic cardiomyopathy (NICM) is a heterogeneous disease, and its prognosis varies. Although late gadolinium enhancement (LGE)-cardiovascular magnetic resonance (CMR) demonstrates a linear pattern in the mid-wall of the septum or multiple LGE lesions in patients with NICM, the thera...

Descripción completa

Detalles Bibliográficos
Autores principales: Ota, Shingo, Orii, Makoto, Nishiguchi, Tsuyoshi, Yokoyama, Mao, Matsushita, Ryoko, Takemoto, Kazushi, Tanimoto, Takashi, Hirata, Kumiko, Hozumi, Takeshi, Akasaka, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992777/
https://www.ncbi.nlm.nih.gov/pubmed/33761955
http://dx.doi.org/10.1186/s12968-021-00734-3
_version_ 1783669449581133824
author Ota, Shingo
Orii, Makoto
Nishiguchi, Tsuyoshi
Yokoyama, Mao
Matsushita, Ryoko
Takemoto, Kazushi
Tanimoto, Takashi
Hirata, Kumiko
Hozumi, Takeshi
Akasaka, Takashi
author_facet Ota, Shingo
Orii, Makoto
Nishiguchi, Tsuyoshi
Yokoyama, Mao
Matsushita, Ryoko
Takemoto, Kazushi
Tanimoto, Takashi
Hirata, Kumiko
Hozumi, Takeshi
Akasaka, Takashi
author_sort Ota, Shingo
collection PubMed
description BACKGROUND: Non-ischemic cardiomyopathy (NICM) is a heterogeneous disease, and its prognosis varies. Although late gadolinium enhancement (LGE)-cardiovascular magnetic resonance (CMR) demonstrates a linear pattern in the mid-wall of the septum or multiple LGE lesions in patients with NICM, the therapeutic response and prognosis of multiple LGE lesions have not been elucidated. This study aimed to investigate the frequency of left ventricular (LV) reverse remodeling (LVRR) and prognosis in patients with NICM who have multiple LGE lesions. METHODS: This single-center retrospective study included 101 consecutive patients with NICM who were divided into 3 groups according to LGE-CMR results: patients without LGE (no LGE group = 48 patients), patients with a typical mid-wall LGE pattern (n = 29 patients), and patients with multiple LGE lesions (n = 24 patients). LVRR was defined as an increase in LV ejection fraction (LVEF) ≥ 10 % and a final value of LVEF > 35 %, which was accompanied by a decrease in LV end-systolic volume ≥ 15 % at 12-month follow-up using echocardiography. The frequency of composite cardiac events, defined as sudden cardiac death (SCD), aborted SCD (non-fatal ventricular fibrillation, sustained ventricular tachycardia, or adequate implantable cardioverter-defibrillator therapies), and heart failure death or hospitalization for worsening heart failure, were summarized and compared between the groups. RESULTS: Among the 3 groups, the frequency of LVRR was significantly lower in the multiple lesions group than in the no LGE and mid-wall groups (no LGE vs. mid-wall vs. multiple lesions: 49 % vs. 52 % vs. 19 %, p = 0.03). There were 24 composite cardiac events among the patients: 2 in patients without LGE (hospitalization for worsening heart failure; 2), 7 in patients of the mid-wall group (SCD; 1, aborted SCD; 1 and hospitalization for worsening heart failure; 5), and 15 in patients of the multiple lesions group (SCD; 1, aborted SCD; 8 and hospitalization for worsening heart failure; 6). The multiple LGE lesions was an independent predictor of composite cardiac events (hazard ratio: 11.40 [95 % confidence intervals: 1.49−92.01], p = 0.020). CONCLUSIONS: Patients with multiple LGE lesions have a higher risk of cardiac events and poorer LVRR. The LGE pattern may be useful for an improved risk stratification in patients with NICM.
format Online
Article
Text
id pubmed-7992777
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-79927772021-03-25 Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy Ota, Shingo Orii, Makoto Nishiguchi, Tsuyoshi Yokoyama, Mao Matsushita, Ryoko Takemoto, Kazushi Tanimoto, Takashi Hirata, Kumiko Hozumi, Takeshi Akasaka, Takashi J Cardiovasc Magn Reson Research BACKGROUND: Non-ischemic cardiomyopathy (NICM) is a heterogeneous disease, and its prognosis varies. Although late gadolinium enhancement (LGE)-cardiovascular magnetic resonance (CMR) demonstrates a linear pattern in the mid-wall of the septum or multiple LGE lesions in patients with NICM, the therapeutic response and prognosis of multiple LGE lesions have not been elucidated. This study aimed to investigate the frequency of left ventricular (LV) reverse remodeling (LVRR) and prognosis in patients with NICM who have multiple LGE lesions. METHODS: This single-center retrospective study included 101 consecutive patients with NICM who were divided into 3 groups according to LGE-CMR results: patients without LGE (no LGE group = 48 patients), patients with a typical mid-wall LGE pattern (n = 29 patients), and patients with multiple LGE lesions (n = 24 patients). LVRR was defined as an increase in LV ejection fraction (LVEF) ≥ 10 % and a final value of LVEF > 35 %, which was accompanied by a decrease in LV end-systolic volume ≥ 15 % at 12-month follow-up using echocardiography. The frequency of composite cardiac events, defined as sudden cardiac death (SCD), aborted SCD (non-fatal ventricular fibrillation, sustained ventricular tachycardia, or adequate implantable cardioverter-defibrillator therapies), and heart failure death or hospitalization for worsening heart failure, were summarized and compared between the groups. RESULTS: Among the 3 groups, the frequency of LVRR was significantly lower in the multiple lesions group than in the no LGE and mid-wall groups (no LGE vs. mid-wall vs. multiple lesions: 49 % vs. 52 % vs. 19 %, p = 0.03). There were 24 composite cardiac events among the patients: 2 in patients without LGE (hospitalization for worsening heart failure; 2), 7 in patients of the mid-wall group (SCD; 1, aborted SCD; 1 and hospitalization for worsening heart failure; 5), and 15 in patients of the multiple lesions group (SCD; 1, aborted SCD; 8 and hospitalization for worsening heart failure; 6). The multiple LGE lesions was an independent predictor of composite cardiac events (hazard ratio: 11.40 [95 % confidence intervals: 1.49−92.01], p = 0.020). CONCLUSIONS: Patients with multiple LGE lesions have a higher risk of cardiac events and poorer LVRR. The LGE pattern may be useful for an improved risk stratification in patients with NICM. BioMed Central 2021-03-25 /pmc/articles/PMC7992777/ /pubmed/33761955 http://dx.doi.org/10.1186/s12968-021-00734-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ota, Shingo
Orii, Makoto
Nishiguchi, Tsuyoshi
Yokoyama, Mao
Matsushita, Ryoko
Takemoto, Kazushi
Tanimoto, Takashi
Hirata, Kumiko
Hozumi, Takeshi
Akasaka, Takashi
Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
title Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
title_full Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
title_fullStr Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
title_full_unstemmed Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
title_short Implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
title_sort implications of multiple late gadolinium enhancement lesions on the frequency of left ventricular reverse remodeling and prognosis in patients with non‐ischemic cardiomyopathy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992777/
https://www.ncbi.nlm.nih.gov/pubmed/33761955
http://dx.doi.org/10.1186/s12968-021-00734-3
work_keys_str_mv AT otashingo implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT oriimakoto implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT nishiguchitsuyoshi implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT yokoyamamao implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT matsushitaryoko implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT takemotokazushi implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT tanimototakashi implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT hiratakumiko implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT hozumitakeshi implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy
AT akasakatakashi implicationsofmultiplelategadoliniumenhancementlesionsonthefrequencyofleftventricularreverseremodelingandprognosisinpatientswithnonischemiccardiomyopathy