EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells

BACKGROUND: Chromosomal inversions involving anaplastic lymphoma kinase (ALK) and echinoderm microtubule associated protein like 4 (EML4) generate a fusion protein EML4-ALK in non-small cell lung cancer (NSCLC). The understanding of EML4-ALK function can be improved by a functional study using norma...

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Detalles Bibliográficos
Autores principales: Miyanaga, Akihiko, Matsumoto, Masaru, Beck, Jessica A., Horikawa, Izumi, Oike, Takahiro, Okayama, Hirokazu, Tanaka, Hiromi, Burkett, Sandra S., Robles, Ana I., Khan, Mohammed, Lissa, Delphine, Seike, Masahiro, Gemma, Akihiko, Mano, Hiroyuki, Harris, Curtis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992817/
https://www.ncbi.nlm.nih.gov/pubmed/33761896
http://dx.doi.org/10.1186/s12885-021-07905-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992817/
https://www.ncbi.nlm.nih.gov/pubmed/33761896
http://dx.doi.org/10.1186/s12885-021-07905-6

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