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EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells
BACKGROUND: Chromosomal inversions involving anaplastic lymphoma kinase (ALK) and echinoderm microtubule associated protein like 4 (EML4) generate a fusion protein EML4-ALK in non-small cell lung cancer (NSCLC). The understanding of EML4-ALK function can be improved by a functional study using norma...
Autores principales: | Miyanaga, Akihiko, Matsumoto, Masaru, Beck, Jessica A., Horikawa, Izumi, Oike, Takahiro, Okayama, Hirokazu, Tanaka, Hiromi, Burkett, Sandra S., Robles, Ana I., Khan, Mohammed, Lissa, Delphine, Seike, Masahiro, Gemma, Akihiko, Mano, Hiroyuki, Harris, Curtis C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992817/ https://www.ncbi.nlm.nih.gov/pubmed/33761896 http://dx.doi.org/10.1186/s12885-021-07905-6 |
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