Combination of EP(4) antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

Prostaglandin E(2) (PGE(2)), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP(1-4)). Specific targeting of EP receptors, as opposed to COX-1/2 inhibition, has...

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Detalles Bibliográficos
Autores principales: Wang, Yun, Cui, Long, Georgiev, Peter, Singh, Latika, Zheng, Yanyan, Yu, Ying, Grein, Jeff, Zhang, Chunsheng, Muise, Eric S., Sloman, David L., Ferguson, Heidi, Yu, Hongshi, Pierre, Cristina St., Dakle, Pranal J, Pucci, Vincenzo, Baker, James, Loboda, Andrey, Linn, Doug, Brynczka, Christopher, Wilson, Doug, Haines, Brian B, Long, Brian, Wnek, Richard, Sadekova, Svetlana, Rosenzweig, Michael, Haidle, Andrew, Han, Yongxin, Ranganath, Sheila H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993229/
https://www.ncbi.nlm.nih.gov/pubmed/33796403
http://dx.doi.org/10.1080/2162402X.2021.1896643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993229/
https://www.ncbi.nlm.nih.gov/pubmed/33796403
http://dx.doi.org/10.1080/2162402X.2021.1896643

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