Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development

Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the dose‐response relationship. To enhance ethical and lo...

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Detalles Bibliográficos
Autores principales: Andrews, Kayla Ann, Owen, Joel S., McCarthy, James, Wesche, David, Gobeau, Nathalie, Grasela, Thaddeus H., Möhrle, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993277/
https://www.ncbi.nlm.nih.gov/pubmed/33326705
http://dx.doi.org/10.1111/cts.12934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993277/
https://www.ncbi.nlm.nih.gov/pubmed/33326705
http://dx.doi.org/10.1111/cts.12934

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