RGD4C peptide mediates anti-p21Ras scFv entry into tumor cells and produces an inhibitory effect on the human colon cancer cell line SW480

BACKGROUND: We prepared an anti-p21Ras scFv which could specifically bind with mutant and wild-type p21Ras. However, it cannot penetrate the cell membrane, which prevents it from binding to p21Ras in the cytoplasm. Here, the RGD4C peptide was used to mediate the scFv penetration into tumor cells and...

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Detalles Bibliográficos
Autores principales: Huang, Chen-Chen, Liu, Fang-Rui, Feng, Qiang, Pan, Xin-Yan, Song, Shu-Ling, Yang, Ju-Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993510/
https://www.ncbi.nlm.nih.gov/pubmed/33765976
http://dx.doi.org/10.1186/s12885-021-08056-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993510/
https://www.ncbi.nlm.nih.gov/pubmed/33765976
http://dx.doi.org/10.1186/s12885-021-08056-4

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