SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice

Pulmonary arterial hypertension (PAH) is a fatal disease whose molecular mechanism is unknown. The trimethylation of lysine 36 on histone 3 (H3K36me3) catalyzed by SETD2 and the modification of N6-methyladenine (m(6)A) mRNA mediated by METTL14 play important roles in a variety of normal and patholog...

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Detalles Bibliográficos
Autores principales: Zhou, Xue-Liang, Huang, Feng-Jian, Li, Yang, Huang, Huang, Wu, Qi-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993666/
https://www.ncbi.nlm.nih.gov/pubmed/33658391
http://dx.doi.org/10.18632/aging.202616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993666/
https://www.ncbi.nlm.nih.gov/pubmed/33658391
http://dx.doi.org/10.18632/aging.202616

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