Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6

Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated in Alzheimer’s patients. To understand SIRT6 role...

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Detalles Bibliográficos
Autores principales: Stein, Daniel, Mizrahi, Amir, Golova, Anastasia, Saretzky, Adam, Venzor, Alfredo Garcia, Slobodnik, Zeev, Kaluski, Shai, Einav, Monica, Khrameeva, Ekaterina, Toiber, Debra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993737/
https://www.ncbi.nlm.nih.gov/pubmed/33690173
http://dx.doi.org/10.18632/aging.202755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993737/
https://www.ncbi.nlm.nih.gov/pubmed/33690173
http://dx.doi.org/10.18632/aging.202755

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