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Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn(2+) in protein glycosylation needed for host cell invasion and intracellular replication
Trypanosoma cruzi is a protist parasite and the causative agent of American trypanosomiasis or Chagas disease. The parasite life cycle in its mammalian host includes an intracellular stage, and glycosylated proteins play a key role in host-parasite interaction facilitating adhesion, invasion and imm...
Autores principales: | Ramakrishnan, Srinivasan, Unger, Linn M., Baptista, Rodrigo P., Cruz-Bustos, Teresa, Docampo, Roberto |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993795/ https://www.ncbi.nlm.nih.gov/pubmed/33720977 http://dx.doi.org/10.1371/journal.ppat.1009399 |
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