EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model

EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in various cell lines and assays, with half-maximal effective concentrations (EC(50)s) of 21, 23 and 64 nM ag...

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Detalles Bibliográficos
Autores principales: Rhodin, Michael H. J., McAllister, Nicole V., Castillo, Jonathan, Noton, Sarah L., Fearns, Rachel, Kim, In Jong, Yu, Jianming, Blaisdell, Thomas P., Panarese, Joseph, Shook, Brian C., Or, Yat Sun, Goodwin, Bryan, Lin, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993833/
https://www.ncbi.nlm.nih.gov/pubmed/33720995
http://dx.doi.org/10.1371/journal.ppat.1009428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993833/
https://www.ncbi.nlm.nih.gov/pubmed/33720995
http://dx.doi.org/10.1371/journal.ppat.1009428

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