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A nuclear-based quality control pathway for non-imported mitochondrial proteins

Mitochondrial import deficiency causes cellular toxicity due to the accumulation of non-imported mitochondrial precursor proteins, termed mitoprotein-induced stress. Despite the burden mis-localized mitochondrial precursors place on cells, our understanding of the systems that dispose of these prote...

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Detalles Bibliográficos
Autores principales: Shakya, Viplendra PS, Barbeau, William A, Xiao, Tianyao, Knutson, Christina S, Schuler, Max H, Hughes, Adam L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993989/
https://www.ncbi.nlm.nih.gov/pubmed/33734083
http://dx.doi.org/10.7554/eLife.61230