Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies

BACKGROUND: Magnesium ions (Mg(2+)) increase and prolong opioid analgesia in chronic and acute pain. The nature of this synergistic analgesic interaction has not yet been explained. Our aim was to investigate whether Mg(2+) alter tramadol pharmacokinetics. Our secondary goal was to assess the safety...

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Detalles Bibliográficos
Autores principales: Rudzki, Piotr J., Jarus-Dziedzic, Katarzyna, Filist, Monika, Gilant, Edyta, Buś-Kwaśnik, Katarzyna, Leś, Andrzej, Sasinowska-Motyl, Małgorzata, Nagraba, Łukasz, Bujalska-Zadrożny, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994227/
https://www.ncbi.nlm.nih.gov/pubmed/33686610
http://dx.doi.org/10.1007/s43440-021-00239-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994227/
https://www.ncbi.nlm.nih.gov/pubmed/33686610
http://dx.doi.org/10.1007/s43440-021-00239-x

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