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Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies
BACKGROUND: Magnesium ions (Mg(2+)) increase and prolong opioid analgesia in chronic and acute pain. The nature of this synergistic analgesic interaction has not yet been explained. Our aim was to investigate whether Mg(2+) alter tramadol pharmacokinetics. Our secondary goal was to assess the safety...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994227/ https://www.ncbi.nlm.nih.gov/pubmed/33686610 http://dx.doi.org/10.1007/s43440-021-00239-x |