In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis

This study aimed to investigate four of the eight PFN-1 mutations that are located near the actin-binding domain and determine the structural changes due to each mutant and unravel how these mutations alter protein structural behavior. Swapaa’s command in UCSF chimera for generating mutations, FTMAP...

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Detalles Bibliográficos
Autores principales: Sadr, Ahmad Shahir, Eslahchi, Changiz, Ghassempour, Alireza, Kiaei, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994392/
https://www.ncbi.nlm.nih.gov/pubmed/33767237
http://dx.doi.org/10.1038/s41598-021-86211-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994392/
https://www.ncbi.nlm.nih.gov/pubmed/33767237
http://dx.doi.org/10.1038/s41598-021-86211-4

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