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The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
Pluripotent cells of the mammalian embryo undergo extensive chromatin rewiring to prepare for lineage commitment after implantation. Repressive H3K27me3, deposited by Polycomb Repressive Complex 2 (PRC2), is reallocated from large blankets in pre-implantation embryos to mark promoters of development...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994559/ https://www.ncbi.nlm.nih.gov/pubmed/33767158 http://dx.doi.org/10.1038/s41467-021-21910-0 |