The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin gene. The neuropathology of HD is characterized by the decline of a specific neuronal population within the brain, the striatal medium spiny neurons (MSNs). The...

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Detalles Bibliográficos
Autores principales: Le Cann, Kim, Foerster, Alec, Rösseler, Corinna, Erickson, Andelain, Hautvast, Petra, Giesselmann, Sebastian, Pensold, Daniel, Kurth, Ingo, Rothermel, Markus, Mattis, Virginia B., Zimmer-Bensch, Geraldine, von Hörsten, Stephan, Denecke, Bernd, Clarner, Tim, Meents, Jannis, Lampert, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994641/
https://www.ncbi.nlm.nih.gov/pubmed/33767215
http://dx.doi.org/10.1038/s41598-021-85656-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994641/
https://www.ncbi.nlm.nih.gov/pubmed/33767215
http://dx.doi.org/10.1038/s41598-021-85656-x

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