Dissection of two routes to naïve pluripotency using different kinase inhibitors

Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...

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Detalles Bibliográficos
Autores principales: Martinez-Val, Ana, Lynch, Cian J., Calvo, Isabel, Ximénez-Embún, Pilar, Garcia, Fernando, Zarzuela, Eduardo, Serrano, Manuel, Munoz, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994667/
https://www.ncbi.nlm.nih.gov/pubmed/33767186
http://dx.doi.org/10.1038/s41467-021-22181-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994667/
https://www.ncbi.nlm.nih.gov/pubmed/33767186
http://dx.doi.org/10.1038/s41467-021-22181-5

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