Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Plasma low-density lipoprotein (LDL) is primarily cleared by LDL receptor (LDLR). LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular milieu. However, the proteinase responsible for LDLR cleavage is unknown. Here we report that membrane type 1-matrix meta...

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Detalles Bibliográficos
Autores principales: Alabi, Adekunle, Xia, Xiao-Dan, Gu, Hong-Mei, Wang, Faqi, Deng, Shi-Jun, Yang, Nana, Adijiang, Ayinuer, Douglas, Donna N., Kneteman, Norman M., Xue, Yazhuo, Chen, Li, Qin, Shucun, Wang, Guiqing, Zhang, Da-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994674/
https://www.ncbi.nlm.nih.gov/pubmed/33767172
http://dx.doi.org/10.1038/s41467-021-22167-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994674/
https://www.ncbi.nlm.nih.gov/pubmed/33767172
http://dx.doi.org/10.1038/s41467-021-22167-3

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