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Trivial and nontrivial error sources account for misidentification of protein partners in mutual information approaches

The problem of finding the correct set of partners for a given pair of interacting protein families based on multi-sequence alignments (MSAs) has received great attention over the years. Recently, the native contacts of two interacting proteins were shown to store the strongest mutual information (M...

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Detalles Bibliográficos
Autores principales: Pontes, Camila, Andrade, Miguel, Fiorote, José, Treptow, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994710/
https://www.ncbi.nlm.nih.gov/pubmed/33767294
http://dx.doi.org/10.1038/s41598-021-86455-0