Genotoxic and oxidative effect of duloxetine on mouse brain and liver tissues

We evaluated the duloxetine DNA damaging capacity utilizing the comet assay applied to mouse brain and liver cells, as well as its DNA, lipid, protein, and nitric oxide oxidative potential in the same cells. A kinetic time/dose strategy showed the effect of 2, 20, and 200 mg/kg of the drug administe...

Descripción completa

Detalles Bibliográficos
Autores principales: Álvarez-González, Isela, Camacho-Cantera, Scarlett, Gómez-González, Patricia, Barrón, Michael J. Rendón, Morales-González, José A., Madrigal-Santillán, Eduardo O., Paniagua-Pérez, Rogelio, Madrigal-Bujaidar, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994804/
https://www.ncbi.nlm.nih.gov/pubmed/33767322
http://dx.doi.org/10.1038/s41598-021-86366-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994804/
https://www.ncbi.nlm.nih.gov/pubmed/33767322
http://dx.doi.org/10.1038/s41598-021-86366-0

Ejemplares similares