Inhibition of ERK 1/2 kinases prevents tendon matrix breakdown

Tendon extracellular matrix (ECM) mechanical unloading results in tissue degradation and breakdown, with niche-dependent cellular stress directing proteolytic degradation of tendon. Here, we show that the extracellular-signal regulated kinase (ERK) pathway is central in tendon degradation of load-de...

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Detalles Bibliográficos
Autores principales: Blache, Ulrich, Wunderli, Stefania L., Hussien, Amro A., Stauber, Tino, Flückiger, Gabriel, Bollhalder, Maja, Niederöst, Barbara, Fucentese, Sandro F., Snedeker, Jess G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994809/
https://www.ncbi.nlm.nih.gov/pubmed/33767224
http://dx.doi.org/10.1038/s41598-021-85331-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994809/
https://www.ncbi.nlm.nih.gov/pubmed/33767224
http://dx.doi.org/10.1038/s41598-021-85331-1

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