FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer

RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. However, the mechanisms underlying the regulation of RNASET2 protein are completely unknown. Here we identified the F-box protein FBXO6, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein)...

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Detalles Bibliográficos
Autores principales: Ji, Mei, Zhao, Zhao, Li, Yue, Xu, Penglin, Shi, Jia, Li, Zhe, Wang, Kaige, Huang, Xiaotian, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994844/
https://www.ncbi.nlm.nih.gov/pubmed/33767133
http://dx.doi.org/10.1038/s41419-021-03580-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994844/
https://www.ncbi.nlm.nih.gov/pubmed/33767133
http://dx.doi.org/10.1038/s41419-021-03580-4

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