Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages

Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the ba...

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Autores principales: Pérez-Morales, Deyanira, Bustamante, Víctor H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994845/
https://www.ncbi.nlm.nih.gov/pubmed/33767154
http://dx.doi.org/10.1038/s41467-021-22198-w
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author Pérez-Morales, Deyanira
Bustamante, Víctor H.
author_facet Pérez-Morales, Deyanira
Bustamante, Víctor H.
author_sort Pérez-Morales, Deyanira
collection PubMed
description Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.
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spelling pubmed-79948452021-04-16 Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages Pérez-Morales, Deyanira Bustamante, Víctor H. Nat Commun Comment Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication. Nature Publishing Group UK 2021-03-25 /pmc/articles/PMC7994845/ /pubmed/33767154 http://dx.doi.org/10.1038/s41467-021-22198-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Pérez-Morales, Deyanira
Bustamante, Víctor H.
Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_full Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_fullStr Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_full_unstemmed Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_short Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_sort cross-kingdom metabolic manipulation promotes salmonella replication inside macrophages
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994845/
https://www.ncbi.nlm.nih.gov/pubmed/33767154
http://dx.doi.org/10.1038/s41467-021-22198-w
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