Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates

Insulin balls, localized insulin amyloids formed at subcutaneous insulin-injection sites in patients with diabetes, cause poor glycemic control owing to impairments in insulin absorption. Our previous study has shown that some insulin balls are cytotoxic, but others are not, implying amyloid polymor...

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Detalles Bibliográficos
Autores principales: Mori, Wakako, Yuzu, Keisuke, Lobsiger, Nadine, Nishioka, Hideo, Sato, Hisako, Nagase, Terumasa, Iwaya, Keiichi, Lindgren, Mikael, Zako, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994847/
https://www.ncbi.nlm.nih.gov/pubmed/33767265
http://dx.doi.org/10.1038/s41598-021-86001-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994847/
https://www.ncbi.nlm.nih.gov/pubmed/33767265
http://dx.doi.org/10.1038/s41598-021-86001-y

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