A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

Steroid receptor coactivator 3 (SRC-3/NCoA3/AIB1), is a key regulator of gene transcription and it plays a central role in breast cancer (BC) tumorigenesis, making it a potential therapeutic target. Beyond its function as an important regulator of estrogen receptor transcriptional activity, SRC-3 al...

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Detalles Bibliográficos
Autores principales: Gilad, Yosi, Eliaz, Yossi, Yu, Yang, Dean, Adam M., Han, San Jung, Qin, Li, O’Malley, Bert W., Lonard, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994904/
https://www.ncbi.nlm.nih.gov/pubmed/33767353
http://dx.doi.org/10.1038/s42003-021-01929-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994904/
https://www.ncbi.nlm.nih.gov/pubmed/33767353
http://dx.doi.org/10.1038/s42003-021-01929-1

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