BOK controls apoptosis by Ca(2+) transfer through ER-mitochondrial contact sites

Calcium transfer from the endoplasmic reticulum (ER) to mitochondria is a critical contributor to apoptosis. B cell lymphoma 2 (BCL-2) ovarian killer (BOK) localizes to the ER and binds the inositol 1,4,5-trisphosophate receptor (IP3R). Here, we show that BOK is necessary for baseline mitochondrial...

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Detalles Bibliográficos
Autores principales: Carpio, Marcos A., Means, Robert E., Brill, Allison L., Sainz, Alva, Ehrlich, Barbara E., Katz, Samuel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995216/
https://www.ncbi.nlm.nih.gov/pubmed/33691099
http://dx.doi.org/10.1016/j.celrep.2021.108827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995216/
https://www.ncbi.nlm.nih.gov/pubmed/33691099
http://dx.doi.org/10.1016/j.celrep.2021.108827

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