ω‐Imidazolyl‐alkyl derivatives as new preclinical drug candidates for treating non‐alcoholic steatohepatitis

Cytochrome P450 2E1 (CYP2E1)‐associated reactive oxygen species production plays an important role in the development and progression of inflammatory liver diseases such as alcoholic steatohepatitis. We developed two new inhibitors for this isoenzyme, namely 12‐imidazolyl‐1‐dodecanol (I‐ol) and 1‐im...

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Detalles Bibliográficos
Autores principales: Diesinger, Torsten, Lautwein, Alfred, Buko, Vyacheslav, Belonovskaya, Elena, Lukivskaya, Oksana, Naruta, Elena, Kirko, Siarhei, Andreev, Viktor, Dvorsky, Radovan, Buckert, Dominik, Bergler, Sebastian, Renz, Christian, Müller‐Enoch, Dieter, Wirth, Thomas, Haehner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995547/
https://www.ncbi.nlm.nih.gov/pubmed/33769703
http://dx.doi.org/10.14814/phy2.14795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995547/
https://www.ncbi.nlm.nih.gov/pubmed/33769703
http://dx.doi.org/10.14814/phy2.14795

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