Cargando…

ω‐Imidazolyl‐alkyl derivatives as new preclinical drug candidates for treating non‐alcoholic steatohepatitis

Cytochrome P450 2E1 (CYP2E1)‐associated reactive oxygen species production plays an important role in the development and progression of inflammatory liver diseases such as alcoholic steatohepatitis. We developed two new inhibitors for this isoenzyme, namely 12‐imidazolyl‐1‐dodecanol (I‐ol) and 1‐im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Diesinger, Torsten, Lautwein, Alfred, Buko, Vyacheslav, Belonovskaya, Elena, Lukivskaya, Oksana, Naruta, Elena, Kirko, Siarhei, Andreev, Viktor, Dvorsky, Radovan, Buckert, Dominik, Bergler, Sebastian, Renz, Christian, Müller‐Enoch, Dieter, Wirth, Thomas, Haehner, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995547/ https://www.ncbi.nlm.nih.gov/pubmed/33769703 http://dx.doi.org/10.14814/phy2.14795

Ejemplares similares

Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis
por: Diesinger, Torsten, et al.
Publicado: (2020)

A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma
por: Diesinger, Torsten, et al.
Publicado: (2021)

Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis
por: Buko, Vyacheslav, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
por: Krauss, Jürgen, et al.
Publicado: (2013)

1,2‐Addition of Diethylzinc to a Bis(Imidazolyl)ketone Ligand
por: Folkertsma, Emma, et al.
Publicado: (2018)

Medicinal Plants Galega officinalis L. and Yacon Leaves as Potential Sources of Antidiabetic Drugs
por: Hachkova, Halyna, et al.
Publicado: (2021)

Design, Synthesis and Evaluation of Antitubercular Activity of Novel Dihydropyridine Containing Imidazolyl Substituent
por: Iman, Maryam, et al.
Publicado: (2015)

Lipid Membrane Adsorption Determines Photodynamic Efficiency of β-Imidazolyl-Substituted Porphyrins
por: Jiménez-Munguía, Irene, et al.
Publicado: (2019)

Imidazolyl activated carbon refluxed with ethanediamine as reusable heterogeneous catalysts for Michael addition
por: Liu, Wenzhu, et al.
Publicado: (2018)

Imidazolyl‐Substituted Benzo‐ and Naphthodithiophenes as Precursors for the Synthesis of Transient Open‐Shell Quinoids
por: Hou, Peng, et al.
Publicado: (2023)

Copper(II) Complexes of Amino Acids and Peptides Containing Chelating bis(imidazolyl) Residues
por: Sóvágó, lmre, et al.
Publicado: (2003)

Different molecular conformations in the crystal structures of three 5-nitroimidazolyl derivatives
por: Osorio, Luis F. B., et al.
Publicado: (2018)

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
por: Novikov, Mikhail S., et al.
Publicado: (2013)

Site-specific functionalization with amino, guanidinium, and imidazolyl groups enabling the activation of 10–23 DNAzyme
por: Du, Shanshan, et al.
Publicado: (2020)

Quantitative Structure-Activity Relationship Studies of 4-Imidazolyl- 1,4-dihydropyridines as Calcium Channel Blockers
por: Hadizadeh, Farzin, et al.
Publicado: (2013)

7-Imidazolyl-substituted 4'-methoxy and 3',4'-dimethoxy-containing polyfluoroflavones as promising antiviral agents
por: Shcherbakov, Konstantin V., et al.
Publicado: (2020)

Excited state dynamics for visible-light sensitization of a photochromic benzil-subsituted phenoxyl-imidazolyl radical
por: Kobayashi, Yoichi, et al.
Publicado: (2019)

Synthesis of asymmetric [bis(imidazolyl)-BH(2)](+)-cation-based ionic liquids as potential rocket fuels
por: Li, Xue, et al.
Publicado: (2021)

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
por: Hamdy, Jehad, et al.
Publicado: (2022)

Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
por: Paramonova, M. P., et al.
Publicado: (2023)

Synthesis of Novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] Dihydropyridines and Studying their Effects on Rat Blood Pressure
por: Mohajeri, Seyed Ahmad, et al.
Publicado: (2011)

Evaluation of anticonvulsant effect of two novels 4-[1-(4-fluorobenzyl)- 5-imidazolyl] dihydropyridine derivatives in mice
por: Hadizadeh, F, et al.
Publicado: (2013)

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides
por: Efimov, Ilya V, et al.
Publicado: (2016)

Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives
por: Paramonova, M. P., et al.
Publicado: (2020)

Imidazolyl Ethanamide Pentandioic Acid (IEPA) as Potential Radical Scavenger during Tumor Therapy in Human Hematopoietic Stem Cells
por: Pfau, Lucas C., et al.
Publicado: (2023)

ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer
por: D’Angelo, Stefania, et al.
Publicado: (2020)

Synthesis, analgesic and anti-inflammatory activities of new methyl-imidazolyl-1,3,4-oxadiazoles and 1,2,4-triazoles
por: Almasirad, Ali, et al.
Publicado: (2014)

On θ(ω) continuity
por: Al Ghour, Samer, et al.
Publicado: (2020)

Increased ω6-Containing Phospholipids and Primary ω6 Oxidation Products in the Brain Tissue of Rats on an ω3-Deficient Diet
por: Axelsen, Paul H., et al.
Publicado: (2016)

Die Uberlieferung Der Hippokratischen Schrift ПEPI AEPΩN YΔatΩNTOПΩN
por: Riesman, David
Publicado: (1933)

Anticonvulsant Effects of New 1, 4-DihydropyridineDerivatives Containing Imidazolyl Moiety Against Seizures Induced by Pentylenetetrazole and Maximal Electroshock in Mice
por: Rasouli, Yasaman, et al.
Publicado: (2017)

Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells
por: Lundberg, Mathias, et al.
Publicado: (2019)

Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice
por: Stoffel, Wilhelm, et al.
Publicado: (2020)

A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male Ldlr (-/-) Mice
por: García-Jaramillo, Manuel, et al.
Publicado: (2019)

The importance of a balanced ω-6 to ω-3 ratio in the prevention and management of obesity
por: Simopoulos, Artemis P, et al.
Publicado: (2016)

Implications of dietary ω-3 and ω-6 polyunsaturated fatty acids in breast cancer
por: Zanoaga, Oana, et al.
Publicado: (2018)

Asymmetric Dissociative Tunneling Ionization of Tetrafluoromethane in ω − 2ω Intense Laser Fields
por: Hasegawa, Hiroka, et al.
Publicado: (2022)

Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency
por: Hammels, Ina, et al.
Publicado: (2019)

Environmentally Benign Water-Soluble Sodium L-2-(1-Imidazolyl) Alkanoic Acids as New Corrosion Inhibitors for Mild Steel in Artificial Seawater
por: Haque, Jiyaul, et al.
Publicado: (2023)

Rare Radiative ω Decays
por: Pietra, C
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_98rjv6njbu1telm2gnc6kco4ql