GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice

Gpr52 is an orphan G-protein-coupled receptor of unknown physiological function. We found that Gpr52-deficient (Gpr52(−/−)) mice exhibit leanness associated with reduced liver weight, decreased hepatic de novo lipogenesis, and enhanced insulin sensitivity. Treatment of the hepatoma cell line HepG2 c...

Descripción completa

Detalles Bibliográficos
Autores principales: Wada, Mitsuo, Yukawa, Kayo, Ogasawara, Hiroyuki, Suzawa, Koichi, Maekawa, Tatsuya, Yamamoto, Yoshihisa, Ohta, Takeshi, Lee, Eunyoung, Miki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995607/
https://www.ncbi.nlm.nih.gov/pubmed/33796846
http://dx.doi.org/10.1016/j.isci.2021.102260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995607/
https://www.ncbi.nlm.nih.gov/pubmed/33796846
http://dx.doi.org/10.1016/j.isci.2021.102260

Ejemplares similares