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GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice

Gpr52 is an orphan G-protein-coupled receptor of unknown physiological function. We found that Gpr52-deficient (Gpr52(−/−)) mice exhibit leanness associated with reduced liver weight, decreased hepatic de novo lipogenesis, and enhanced insulin sensitivity. Treatment of the hepatoma cell line HepG2 c...

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Detalles Bibliográficos
Autores principales:	Wada, Mitsuo, Yukawa, Kayo, Ogasawara, Hiroyuki, Suzawa, Koichi, Maekawa, Tatsuya, Yamamoto, Yoshihisa, Ohta, Takeshi, Lee, Eunyoung, Miki, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995607/ https://www.ncbi.nlm.nih.gov/pubmed/33796846 http://dx.doi.org/10.1016/j.isci.2021.102260

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