Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver

HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol biosynthesis and the target for cholesterol-lowering therapy. Acetaldehyde dehydrogenase 2 (ALDH2) is primarily responsible for detoxifying ethanol-derived acetaldehyde and endogenous lipid aldehydes derived from lipid peroxidation...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Shanshan, Li, Luxiao, Liang, Ningning, Zhang, Lili, Xu, Xiaodong, Chen, Shiting, Yin, Huiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995661/
https://www.ncbi.nlm.nih.gov/pubmed/33740503
http://dx.doi.org/10.1016/j.redox.2021.101919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995661/
https://www.ncbi.nlm.nih.gov/pubmed/33740503
http://dx.doi.org/10.1016/j.redox.2021.101919

Ejemplares similares