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Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver

HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol biosynthesis and the target for cholesterol-lowering therapy. Acetaldehyde dehydrogenase 2 (ALDH2) is primarily responsible for detoxifying ethanol-derived acetaldehyde and endogenous lipid aldehydes derived from lipid peroxidation...

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Detalles Bibliográficos
Autores principales:	Zhong, Shanshan, Li, Luxiao, Liang, Ningning, Zhang, Lili, Xu, Xiaodong, Chen, Shiting, Yin, Huiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995661/ https://www.ncbi.nlm.nih.gov/pubmed/33740503 http://dx.doi.org/10.1016/j.redox.2021.101919

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