Cargando…

Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling

BACKGROUND: Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation. This study aimed to investigate how LPS regulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	AlQranei, Mohammed S., Senbanjo, Linda T., Aljohani, Hanan, Hamza, Therwa, Chellaiah, Meenakshi A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995782/ https://www.ncbi.nlm.nih.gov/pubmed/33765924 http://dx.doi.org/10.1186/s12865-021-00409-9

Ejemplares similares

C-phycocyanin attenuates RANKL-induced osteoclastogenesis and bone resorption in vitro through inhibiting ROS levels, NFATc1 and NF-κB activation
por: AlQranei, Mohammed S., et al.
Publicado: (2020)

Identification of sequence-specific interactions of the CD44-intracellular domain with RUNX2 in the transcription of matrix metalloprotease-9 in human prostate cancer cells
por: Senbanjo, Linda T., et al.
Publicado: (2020)

Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice
por: Aljohani, Hanan, et al.
Publicado: (2021)

Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells
por: Aljohani, Hanan, et al.
Publicado: (2019)

Characterization of CD44 intracellular domain interaction with RUNX2 in PC3 human prostate cancer cells
por: Senbanjo, Linda T., et al.
Publicado: (2019)

Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice
por: Aljohani, Hanan, et al.
Publicado: (2021)

Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis
por: Chakraborty, Sushmita, et al.
Publicado: (2017)

CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells
por: Senbanjo, Linda T., et al.
Publicado: (2017)

Hippuric acid and 3‐(3‐hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL‐RANK independent pathway
por: Zhao, Haijun, et al.
Publicado: (2019)

Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity
por: Hur, Jeonghwan, et al.
Publicado: (2016)

The molecular mechanism of osteoclastogenesis: ODF/RANKL-dependent and independent pathways
por: Suda, T, et al.
Publicado: (2001)

Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL
por: Jang, Yuria, et al.
Publicado: (2021)

TNF-α and RANKL promote osteoclastogenesis by upregulating RANK via the NF-κB pathway
por: Luo, Gang, et al.
Publicado: (2018)

Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption
por: Niu, Chenguang, et al.
Publicado: (2017)

Quantitation of the Rank-Rankl Axis in Primary Biliary Cholangitis
por: Lleo, Ana, et al.
Publicado: (2016)

Targeting the RANKL/RANK/OPG Axis for Cancer Therapy
por: Ming, Jie, et al.
Publicado: (2020)

Puerarin inhibits the osteoclastogenesis by inhibiting RANKL-dependent and –independent autophagic responses
por: Zhang, Guoyou, et al.
Publicado: (2019)

RANKL-independent osteoclastogenesis in the SH3BP2 cherubism mice
por: Kittaka, Mizuho, et al.
Publicado: (2020)

Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo
por: Peng, Jiaxuan, et al.
Publicado: (2020)

Dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients
por: Alfaqih, Mahmoud A., et al.
Publicado: (2018)

The RANKL-RANK Axis: A Bone to Thymus Round Trip
por: Sobacchi, Cristina, et al.
Publicado: (2019)

Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta
por: Passaponti, Sofia, et al.
Publicado: (2022)

Mitf Induction by RANKL Is Critical for Osteoclastogenesis
por: Lu, Ssu-Yi, et al.
Publicado: (2010)

(5R)-5-Hydroxytriptolide (LLDT-8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway
por: Shen, Yi, et al.
Publicado: (2015)

Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women
por: Abdi, Saba, et al.
Publicado: (2020)

The Role of the RANKL/RANK Axis in the Prevention and Treatment of Breast Cancer with Immune Checkpoint Inhibitors and Anti-RANKL
por: Simatou, Aristofania, et al.
Publicado: (2020)

Peptidomimetic inhibitors of L-plastin reduce the resorptive activity of osteoclast but not the bone forming activity of osteoblasts in vitro
por: Chellaiah, Meenakshi A., et al.
Publicado: (2018)

Artesunate inhibits osteoclastogenesis through the miR-503/RANK axis
por: Huang, Ming-Zhi, et al.
Publicado: (2020)

RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages
por: Mota, Ryerson Fonseca, et al.
Publicado: (2022)

RANKL-induced DC-STAMP Is Essential for Osteoclastogenesis
por: Kukita, Toshio, et al.
Publicado: (2004)

TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis
por: Yang, Yu-Mi, et al.
Publicado: (2013)

RANKL Signaling and Osteoclastogenesis Is Negatively Regulated by Cardamonin
por: Sung, Bokyung, et al.
Publicado: (2013)

Biology of RANK, RANKL, and osteoprotegerin
por: Boyce, Brendan F, et al.
Publicado: (2007)

RANK–RANKL signalling in cancer
por: Renema, Nathalie, et al.
Publicado: (2016)

Integrin αvβ3 and CD44 pathways in metastatic prostate cancer cells support osteoclastogenesis via a Runx2/Smad 5/receptor activator of NF-κB ligand signaling axis
por: Gupta, Aditi, et al.
Publicado: (2012)

Roles of the RANKL–RANK Axis in Immunity—Implications for Pathogenesis and Treatment of Bone Metastasis
por: Li, Bo, et al.
Publicado: (2022)

Androgen receptor expression reduces stemness characteristics of prostate cancer cells (PC3) by repression of CD44 and SOX2
por: Srinivasan, Deepa, et al.
Publicado: (2018)

Magnesium Lithospermate B Protects against Lipopolysaccharide-Induced Bone Loss by Inhibiting RANKL/RANK Pathway
por: Wang, Jihai, et al.
Publicado: (2018)

Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway
por: Wu, Xinhui, et al.
Publicado: (2021)

Attenuated RANKL-induced cytotoxicity by Portulaca oleracea ethanol extract enhances RANKL-mediated osteoclastogenesis
por: Erkhembaatar, Munkhsoyol, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kj2gpdf4rpbkj2s2fbeun710es