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Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclusive about the molecular effect on the tissue, desp...

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Detalles Bibliográficos
Autores principales: Acosta, Monica L., Mat Nor, Mohd N., Guo, Cindy X., Mugisho, Odunayo O., Coutinho, Frazer P., Rupenthal, Ilva D., Green, Colin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996017/
https://www.ncbi.nlm.nih.gov/pubmed/32985469
http://dx.doi.org/10.4103/1673-5374.290097