p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53

p53 is the most frequently mutated or inactivated gene in cancer, as its activity is not reconcilable with tumor onset and progression. Moreover, mutations in the p53 gene give rise to mutant proteins such as p53-R273H that, besides losing the wild type p53 (wtp53) capacity to safeguard genome integ...

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Detalles Bibliográficos
Autores principales: Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Benedetti, Rossella, Arena, Andrea, D’Orazi, Gabriella, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996167/
https://www.ncbi.nlm.nih.gov/pubmed/33668399
http://dx.doi.org/10.3390/biom11030344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996167/
https://www.ncbi.nlm.nih.gov/pubmed/33668399
http://dx.doi.org/10.3390/biom11030344

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